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![]() The volume of distribution is used to calculate the loading dose of a drug that will immediately achieve a desired steady-state concentration. ![]() ![]() The volume of distribution is a proportionality constant that relates the amount of drug in the body to the serum concentration. Physiologically, clearance is determined by blood flow to the organ that metabolizes or eliminates the drug and the efficiency of the organ in extracting the drug from the bloodstream. Clinical pharmacokinetics is the discipline that describes the absorption, distribution, metabolism, and elimination of drugs in patients requiring drug therapy.Ĭlearance is the most important pharmacokinetic parameter because it determines the steady-state concentration for a given dosage rate.
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